Surface Epithelial Cell Damage Induced by Restraint and Water-Immersion Stress in Rats Effects of 16,16-Dimethyl Prostaglandin E2 on Stress-Induced Gastric Lesions
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Hypothalamic Astrocytes Respond to Gastric Mucosal Damage Induced by Restraint Water-Immersion Stress in Rat
Restraint water-immersion stress (RWIS), a compound stress model, includes both psychological and physical stimulation. Studies have shown that neurons in the hypothalamus are involved in RWIS, but the role of astrocytes and the interactions between astrocytes and neurons in RWIS are not clear. Here, we tested our hypothesis that hypothalamus astrocytes are involved in RWIS and interact with ne...
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The role of antimuscarinic action in gastric mucosal protection against necrotizing agents and the role of such mucosal protection in antiulcerogenic action were studied in rats with i.v. administered antimuscarinic agents. Pirenzepine, as well as PGE2, prevented the gastric mucosal lesions induced by all necrotizing agents (99.5% ethanol, 0.6 N HCI, 0.15 N NaOH, 0.4 N HCI-50 mM taurocholate), ...
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The effect of 16,16-dimethyl prostaglandin E2 (dmPGE2) on gastric surface epithelial cell (SEC) damage induced by vagal nerve stimulation (VS) in urethane-anesthetized rats was studied using scanning electron microscopy. VS (1.25-10 Hz, 0.2 mA, 2 msec, 10 min) resulted in a graded increase in the SEC damage, increased gastric contractions, increased gastric acid secretion, and a decrease in hea...
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Background: Escin was a natural mixture of triterpenoid saponin that was isolated from the seed of the horse chestnut. The previous study from our laboratory demonstrated that escin had a protective effect against indomethacin-induced gastric ulcers in mice. The aim of this study was to investigate the effect of escin on gastric mucosal lesions induced by water immersion and restraint stress (W...
متن کاملGastroprotective effects of β3-adrenoceptor agonists on water immersion plus restraint stress-induced gastric ulcer in rats
Objective: To evaluate the gastroprotective effects of β 3 -adrenoceptor agonists CGP 12177A and SR 58611A, on water immersion plus restraint stress (WIRS)-induced gastric ulceration in rats. Material and Methods: Drugs were administered (5, 10 and 15 mg/kg, p.o. ) 30 min prior to the ulcerogenic procedure. Ulcer index and the score for intensity of intraluminal bleeding were determined. Gastri...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1987
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)43397-0